GHSA-r9hx-vwmv-q579 is a high-severity (CVSS 7.5) CWE-1333 vulnerability in setuptools. 1 public exploit reference exists, so weaponization risk is real. O3 Security confirms whether GHSA-r9hx-vwmv-q579 is actually reachable in your code before you act, and blocks exploitation at runtime until you patch.
pypa/setuptools vulnerable to Regular Expression Denial of Service (ReDoS)
Exploitation Status
No confirmed exploitation observed yet
- CISA’s own triage has not observed active exploitation or public proof-of-concept code for this CVE as of its last assessment.
Exploitation and automatability from CISA’s SSVC triage for GHSA-r9hx-vwmv-q579.
EPSS Exploitation Probability
EPSS (Exploit Prediction Scoring System) is a daily probability model maintained by FIRST.org. It estimates the likelihood a CVE will be exploited in production environments within the next 30 days, derived from real-world threat intelligence signals.
How urgent is this, really
GHSA-r9hx-vwmv-q579 plotted by exploitation likelihood (EPSS) against impact (CVSS). The shaded corner — EPSS 50%+ and CVSS 7.0+ — is where this CVE doesn't sit, though severity or exploitability alone can still warrant action.
Where this sits among everything scored
Of 0 CVEs with a current EPSS score, this one falls in the < 10% band (highlighted). Real counts from FIRST.org, not a sample — log-scaled since the landscape is heavily right-skewed.
Real-World Exposure
setuptoolsReal-time download stats are indexed for npm and PyPI packages. This vulnerability affects PyPI packages — download data is not available via public APIs for these ecosystems.
Description
Python Packaging Authority (PyPA)'s setuptools is a library designed to facilitate packaging Python projects. Setuptools version 65.5.0 and earlier could allow remote attackers to cause a denial of service by fetching malicious HTML from a PyPI package or custom PackageIndex page due to a vulnerable Regular Expression in package_index. This has been patched in version 65.5.1.
Affected Packages
| Ecosystem | Package | Vulnerable range | Fix |
|---|---|---|---|
| 🐍PyPI | setuptools | all versions | 65.5.1 |
Research use only. For defensive security, authorized penetration testing, and academic research only. Never execute exploit code against systems without explicit written authorization.
Detection & mitigation playbook
Open-source dependencyDetect
Scan your dependency tree (package-lock.json, pnpm-lock.yaml, requirements.txt, go.sum, etc.) for setuptools. O3's reachability analysis confirms whether the vulnerable code path is actually invoked in your application, so you act on real exposure instead of every transitive match.
Fix
Update setuptools to 65.5.1 or later, then make sure no transitive (indirect) dependency still pins the vulnerable range — O3 confirms GHSA-r9hx-vwmv-q579 is resolved across your whole dependency graph.
Workarounds
If you can't upgrade right away: gate or disable the affected feature, validate untrusted input at the boundary, and avoid passing attacker-controlled data into the vulnerable path. O3's runtime protection blocks exploitation in production as an interim safeguard until the upgrade lands.
How O3 protects you
O3 pinpoints whether GHSA-r9hx-vwmv-q579 is reachable in your code and exactly where to fix it, then blocks exploitation in production at runtime until the patched version is deployed.
Tailored to GHSA-r9hx-vwmv-q579. Runtime protection reduces exposure until a permanent patch is applied and verified — it complements patching, it doesn't replace it.
Fixing This On Your OS
If you run this on a Linux distribution, patch through your package manager against the distro's own security advisory below — it tracks the exact backported fix for your release, which can ship on a different timeline (and sometimes a different severity) than the upstream project.
Frequently Asked Questions
Is GHSA-r9hx-vwmv-q579 in your dependencies?
O3 detects GHSA-r9hx-vwmv-q579 across PyPI dependencies and uses function-level reachability to confirm whether the vulnerable code path is actually reachable — not just present. No false positives.