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Not in CISA KEV
HIGH severity

HTSJDK is vulnerable to exposure of resource(s) to the wrong sphereGHSA-96vh-4rfp-c42c

HIGHFix: samtools/htsjdk#1617

GHSA-96vh-4rfp-c42c is a high-severity (CVSS 7.8) CWE-668 vulnerability in com.github.samtools:htsjdk. 1 public exploit or proof-of-concept reference is indexed, so weaponization risk is real. A fix is available for com.github.samtools:htsjdk — see the affected versions and patch details below.

Also known asCVE-2022-21126
Published
Updated
Affected
1 pkg
Patched
1 / 1
Exploits
1 known
Exploitation data as of Nov 7, 2026 · OSV.dev, NVD, FIRST.org (EPSS)

Exploitation Status

Proof-of-concept exploit code exists

  • CISA’s SSVC triage found public proof-of-concept exploit code for this CVE, though no confirmed active exploitation.

Exploitation and automatability from CISA’s SSVC triage for GHSA-96vh-4rfp-c42c.

EPSS Exploitation Probability

via FIRST.org ↗
0.8%probability of exploitation in next 30 days
Lower Risk+0.01%
Lower risk than most CVEs55th percentile — riskier than 55% of all scored CVEsHighest risk
0.00%0.42%0.84%1.25%0.2%0.8%May 26Sep 26Nov 26

Probability of exploitation in the next 30 days, from FIRST.org EPSS.

How urgent is this, really

Where this sits among everything scored

Real-World Exposure

1 pkg affected
☕com.github.samtools:htsjdk

Real-time download stats are indexed for npm and PyPI packages. This vulnerability affects Maven packages — download data is not available via public APIs for these ecosystems.

Description

The package com.github.samtools:htsjdk before 3.0.1 are vulnerable to Creation of Temporary File in Directory with Insecure Permissions due to the createTempDir() function in util/IOUtil.java not checking for the existence of the temporary directory before attempting to create it.

Affected Packages

1 total 1 fixed
EcosystemPackageVulnerable rangeFix
☕Mavencom.github.samtools:htsjdkall versions3.0.1com.github.samtools:htsjdk:3.0.1

Affected Products

1 product · 1 configurations
Application
htsjdksamtools
< 3.0.1
range
Exploits & PoCs
1

Research use only. For defensive security, authorized penetration testing, and academic research only. Never execute exploit code against systems without explicit written authorization.

The package com.github.samtools:htsjdk before 3.0.1 are vulnerable to Cr…

github.comNVDDec 2022

Detection & mitigation playbook

Open-source dependency

  1. Detect

    Scan your dependency tree (package-lock.json, pnpm-lock.yaml, requirements.txt, go.sum, etc.) for com.github.samtools:htsjdk, including transitive dependencies — a direct dependency you never call can still pull in a vulnerable version.

  2. Fix

    Update com.github.samtools:htsjdk to 3.0.1 or later, then make sure no transitive (indirect) dependency still pins the vulnerable range — O3 confirms GHSA-96vh-4rfp-c42c is resolved across your whole dependency graph.

  3. Workarounds

    If you can't upgrade right away: gate or disable the affected feature, validate untrusted input at the boundary, and avoid passing attacker-controlled data into the vulnerable path. O3's runtime protection blocks exploitation in production as an interim safeguard until the upgrade lands.

Frequently Asked Questions

The package com.github.samtools:htsjdk before 3.0.1 are vulnerable to Creation of Temporary File in Directory with Insecure Permissions due to the createTempDir() function in util/IOUtil.java not checking for the existence of the temporary directory before attempting to create it.
O3 Security · Impact-Aware SCA

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HTSJDK is vulnerable to exposure of resource(s) to the…