CVE-2022-43607
HIGHCVE-2022-43607 is a high-severity (CVSS 7.8) Buffer Overflow vulnerability in openbabel. 1 public exploit reference exists, so weaponization risk is real. O3 Security confirms whether CVE-2022-43607 is actually reachable in your code before you act, and blocks exploitation at runtime until you patch.
Open Babel has out-of-bounds write in MOL2 attribute/value parser
Exploitation Status
Proof-of-concept exploit code exists
- CISA’s SSVC triage found public proof-of-concept exploit code for this CVE, though no confirmed active exploitation.
- A successful exploit gives an attacker total control of the affected component, not partial access.
Exploitation and automatability from CISA’s SSVC triage for CVE-2022-43607.
EPSS Exploitation Probability
EPSS (Exploit Prediction Scoring System) is a daily probability model maintained by FIRST.org. It estimates the likelihood a CVE will be exploited in production environments within the next 30 days, derived from real-world threat intelligence signals.
How urgent is this, really
CVE-2022-43607 plotted by exploitation likelihood (EPSS) against impact (CVSS). The shaded corner — EPSS 50%+ and CVSS 7.0+ — is where this CVE doesn't sit, though severity or exploitability alone can still warrant action.
Where this sits among everything scored
Of 0 CVEs with a current EPSS score, this one falls in the < 10% band (highlighted). Real counts from FIRST.org, not a sample — log-scaled since the landscape is heavily right-skewed.
Real-World Exposure
openbabelReal-time download stats are indexed for npm and PyPI packages. This vulnerability affects PyPI packages — download data is not available via public APIs for these ecosystems.
Description
An out-of-bounds write vulnerability exists in the MOL2 format attribute and value functionality of Open Babel 3.1.1 and master commit 530dbfa3. A specially crafted malformed file can lead to arbitrary code execution. An attacker can provide a malicious file to trigger this vulnerability.
Affected Packages
| Ecosystem | Package | Vulnerable range | Fix |
|---|---|---|---|
| 🐍PyPI | openbabel | all versions | 3.2.0 |
Research use only. For defensive security, authorized penetration testing, and academic research only. Never execute exploit code against systems without explicit written authorization.
Detection & mitigation playbook
Open-source dependencyDetect
Scan your dependency tree (package-lock.json, pnpm-lock.yaml, requirements.txt, go.sum, etc.) for openbabel. O3's reachability analysis confirms whether the vulnerable code path is actually invoked in your application, so you act on real exposure instead of every transitive match.
Fix
Update openbabel to 3.2.0 or later, then make sure no transitive (indirect) dependency still pins the vulnerable range — O3 confirms CVE-2022-43607 is resolved across your whole dependency graph.
Workarounds
If you can't upgrade right away: gate or disable the affected feature, validate untrusted input at the boundary, and avoid passing attacker-controlled data into the vulnerable path. O3's runtime protection blocks exploitation in production as an interim safeguard until the upgrade lands.
How O3 protects you
O3 pinpoints whether CVE-2022-43607 is reachable in your code and exactly where to fix it, then blocks exploitation in production at runtime until the patched version is deployed.
Tailored to CVE-2022-43607. Runtime protection reduces exposure until a permanent patch is applied and verified — it complements patching, it doesn't replace it.
Frequently Asked Questions
Is CVE-2022-43607 in your dependencies?
O3 detects CVE-2022-43607 across PyPI dependencies and uses function-level reachability to confirm whether the vulnerable code path is actually reachable — not just present. No false positives.