Your RSA-2048 keys break in 2030. Find every one of them before attackers do.
🛡️
Not in CISA KEV
MEDIUM severity

CVE-2021-25921 — openemr

MEDIUMFix: openemr/openemr@0fadc3e

CVE-2021-25921 is a medium-severity (CVSS 5.4) Cross-site Scripting (XSS) vulnerability. EPSS puts its 30-day exploitation probability at 91.1% (100th percentile). A fix is available — see the affected versions and patch details below.

Published
Updated
Affected
1 product
Patched
See advisory
Exploits
None indexed
Exploitation data as of Oct 27, 2026 · OSV.dev, NVD, FIRST.org (EPSS)

Exploitation Status

Proof-of-concept exploit code exists

  • CISA’s SSVC triage found public proof-of-concept exploit code for this CVE, though no confirmed active exploitation.

Exploitation and automatability from CISA’s SSVC triage for CVE-2021-25921.

EPSS Exploitation Probability

via FIRST.org ↗
91.1%probability of exploitation in next 30 days
Very High Risk0.00%
Lower risk than most CVEs100th percentile — riskier than 100% of all scored CVEsHighest risk
12.4%41.6%70.8%100.0%57.1%91.1%Apr 26Aug 26Oct 26

Probability of exploitation in the next 30 days, from FIRST.org EPSS.

How urgent is this, really

CVE-2021-25921 by exploitation likelihood (EPSS) against impact (CVSS). Outside the shaded patch-first corner.

Where this sits among everything scored

Of 396,966 CVEs with a current EPSS score, this one falls in the ≥ 90% band (highlighted). Counts from FIRST.org, log-scaled.

Description

In OpenEMR, versions 2.7.3-rc1 to 6.0.0 are vulnerable to Stored Cross-Site-Scripting (XSS) due to user input not being validated properly in the Allergies section. An attacker could lure an admin to enter a malicious payload and by that initiate the exploit.

Affected Products

1 product · 1 configurations
Application
openemropen-emr
≥ 2.7.3 && ≤ 6.0.0
range

Detection & mitigation playbook

Vulnerability

  1. Detect

    Identify every host running the affected component and compare the installed build against the fixed version below — for source-built or distro-packaged software the version string, not a lockfile, is the source of truth (`dpkg -l`, `rpm -q`, or the binary's own `--version`).

  2. Fix

    Upgrade the affected component to the fixed release for CVE-2021-25921, or apply your distribution's backported patch — distro builds are often patched at an older version number, so check your vendor's advisory rather than the upstream version alone.

  3. Workarounds

    Escape or sanitise the affected output on the server side rather than relying on client-side filtering, and add a Content-Security-Policy that blocks inline script execution so injected markup cannot run even if it reaches the page.

Frequently Asked Questions

In OpenEMR, versions 2.7.3-rc1 to 6.0.0 are vulnerable to Stored Cross-Site-Scripting (XSS) due to user input not being validated properly in the `Allergies` section. An attacker could lure an admin to enter a malicious payload and by that initiate the exploit.
O3 Security · Impact-Aware SCA

Is CVE-2021-25921 in your dependencies?

Find it across , including transitive dependencies.

Scan my dependencies How O3 SCA works
CVE-2021-25921: openemr XSS (Medium 5.4)