CVE-2026-100845 — Project-MONAI
HIGHCVE-2026-100845 is a high-severity (CVSS 7.8) Deserialization of Untrusted Data vulnerability. No vendor fix is recorded yet; mitigation options are listed below.
MONAI before 1.6.0 contains an unsafe deserialization vulnerability in the NumpyReader class that unconditionally uses numpy.load with allow_pickle=True when loading .npy and .npz files.…
Description
MONAI before 1.6.0 contains an unsafe deserialization vulnerability in the NumpyReader class that unconditionally uses numpy.load with allow_pickle=True when loading .npy and .npz files. Attackers can craft malicious .npy files with pickle payloads that execute arbitrary code when loaded through MONAI's standard data pipeline.
Detection & mitigation playbook
VulnerabilityDetect
Identify every host running the affected component and compare the installed build against the fixed version below — for source-built or distro-packaged software the version string, not a lockfile, is the source of truth (`dpkg -l`, `rpm -q`, or the binary's own `--version`). Because remote code execution targets the running service rather than your application code, O3 also flags the exploit behaviour from runtime telemetry and egress traffic.
Remediation status
No fixed release is recorded for CVE-2026-100845 yet. Track the upstream advisory, and apply the exposure-reduction steps below in the meantime.
Mitigate without a patch
Do not deserialise data from untrusted sources: where the format allows it, restrict deserialisation to an explicit allowlist of expected types, and prefer a data-only format (JSON, Protobuf) over one that can reconstruct arbitrary objects until you can upgrade. O3's runtime protection blocks the deserialization of untrusted data flaw at execution, which holds the line on hosts you cannot patch immediately.
How O3 protects you
O3 detects and blocks CVE-2026-100845 exploitation at runtime with eBPF exploit-chain detection, plus L7 egress monitoring that catches a post-exploitation callback and cuts the attacker's outbound channel.
Tailored to CVE-2026-100845. Runtime protection reduces exposure until a permanent patch is applied and verified — it complements patching, it doesn't replace it.
Frequently Asked Questions
Is CVE-2026-100845 in your dependencies?
O3 Security finds CVE-2026-100845 across dependencies, including transitive ones, and its impact-aware SCA ranks findings by whether your code actually calls the vulnerable path.