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Not in CISA KEV
HIGH severity

CVE-2026-100843 — Project-MONAI

HIGH

CVE-2026-100843 is a high-severity (CVSS 7.8) Deserialization of Untrusted Data vulnerability. No vendor fix is recorded yet; mitigation options are listed below.

MONAI versions before 1.6.0 contain a remote code execution vulnerability in the algo_from_pickle() function due to unsafe pickle.loads() deserialization in monai/auto3dseg/utils.py.…

Published
Sep 27, 2026
Updated
Sep 27, 2026
Affected
—
Patched
—
Exploits
None indexed
Exploitation data as of Sep 27, 2026 · OSV.dev, NVD, FIRST.org (EPSS)

Description

MONAI versions before 1.6.0 contain a remote code execution vulnerability in the algo_from_pickle() function due to unsafe pickle.loads() deserialization in monai/auto3dseg/utils.py. Attackers can craft malicious pickle files that execute arbitrary system commands when deserialized by the vulnerable function.

Detection & mitigation playbook

Vulnerability
  1. Detect

    Identify every host running the affected component and compare the installed build against the fixed version below — for source-built or distro-packaged software the version string, not a lockfile, is the source of truth (`dpkg -l`, `rpm -q`, or the binary's own `--version`). Because remote code execution targets the running service rather than your application code, O3 also flags the exploit behaviour from runtime telemetry and egress traffic.

  2. Remediation status

    No fixed release is recorded for CVE-2026-100843 yet. Track the upstream advisory, and apply the exposure-reduction steps below in the meantime.

  3. Mitigate without a patch

    Do not deserialise data from untrusted sources: where the format allows it, restrict deserialisation to an explicit allowlist of expected types, and prefer a data-only format (JSON, Protobuf) over one that can reconstruct arbitrary objects until you can upgrade. O3's runtime protection blocks the deserialization of untrusted data flaw at execution, which holds the line on hosts you cannot patch immediately.

  4. How O3 protects you

    O3 detects and blocks CVE-2026-100843 exploitation at runtime with eBPF exploit-chain detection, plus L7 egress monitoring that catches a post-exploitation callback and cuts the attacker's outbound channel.

Tailored to CVE-2026-100843. Runtime protection reduces exposure until a permanent patch is applied and verified — it complements patching, it doesn't replace it.

Frequently Asked Questions

MONAI versions before 1.6.0 contain a remote code execution vulnerability in the algo_from_pickle() function due to unsafe pickle.loads() deserialization in monai/auto3dseg/utils.py. Attackers can craft malicious pickle files that execute arbitrary system commands when deserialized by the vulnerable function.
O3 Security · Impact-Aware SCA

Is CVE-2026-100843 in your dependencies?

O3 Security finds CVE-2026-100843 across dependencies, including transitive ones, and its impact-aware SCA ranks findings by whether your code actually calls the vulnerable path.