How severe is CVE-2021-41132?

CVE-2021-41132 has a CVSS score of 6.1/10, rated MEDIUM. Review your exposure and patch according to your risk tolerance.

Which packages are affected by CVE-2021-41132?

CVE-2021-41132 affects the following packages: omero-web (PyPI), omero-figure (PyPI). Ecosystems affected: PyPI.

How do I fix CVE-2021-41132?

Update omero-web to 5.11.0 or later, then make sure no transitive (indirect) dependency still pins the vulnerable range — O3 confirms CVE-2021-41132 is resolved across your whole dependency graph.

How do I detect CVE-2021-41132 in my PyPI dependencies?

Scan your dependency tree (package-lock.json, pnpm-lock.yaml, requirements.txt, go.sum, etc.) for omero-web, including transitive dependencies — a direct dependency you never call can still pull in a vulnerable version.

How do I mitigate CVE-2021-41132 if there is no patch (or I can't update yet)?

Escape or sanitise the affected output on the server side rather than relying on client-side filtering, and add a Content-Security-Policy that blocks inline script execution so injected markup cannot run even if it reaches the page.

Is CVE-2021-41132 actively exploited in the wild?

No public exploit code has been indexed for CVE-2021-41132 yet. This does not mean the vulnerability cannot be exploited — absence of public exploits does not imply safety. Apply the recommended fix and use O3 Security to monitor your exposure.

What is the EPSS score for CVE-2021-41132?

CVE-2021-41132 has an EPSS (Exploit Prediction Scoring System) score of 1.0%, placing it in the 64th percentile of all CVEs. EPSS is maintained by FIRST.org and estimates the probability that a vulnerability will be exploited in the wild within the next 30 days. This score indicates relatively lower exploitation probability, though the CVSS severity should still guide your patching priority.

What type of vulnerability is CVE-2021-41132?

CVE-2021-41132 is classified as CWE-116 (CWE-116), Cross-site Scripting (XSS) (CWE-79). These weakness types describe the underlying flaw category, which helps determine the potential impact and the right class of mitigation. This is a high-impact weakness class that often enables remote code execution or data exposure.

When was CVE-2021-41132 published, and has it been updated?

CVE-2021-41132 was published on October 14, 2021 and was last updated on November 10, 2026. Advisory data evolves as severity scores, affected ranges, and exploit intelligence are revised — always check the latest version of the advisory before acting.

🐍

🐍 PyPI

Not in CISA KEV

MEDIUM severity

CVE-2021-41132 — omero-web

MEDIUMFix: ome/omero-web@0168067

CVE-2021-41132 is a medium-severity (CVSS 6.1) CWE-116 vulnerability in omero-web. A fix is available for omero-web — see the affected versions and patch details below.

Inconsistent input sanitisation leads to XSS vectors

Also known asGHSA-g67g-hvc3-xmvfPYSEC-2021-372PYSEC-2021-379

Published

Oct 14, 2021

Updated

Nov 10, 2026

Affected

2 pkgs

Patched

2 / 2

Exploits

None indexed

Exploitation data as of Nov 9, 2026 · OSV.dev, NVD, FIRST.org (EPSS)

EPSS Exploitation Probability

via FIRST.org ↗

1.0%probability of exploitation in next 30 days

Lower Risk0.00%

Lower risk than most CVEs64th percentile — riskier than 64% of all scored CVEsHighest risk

Probability of exploitation in the next 30 days, from FIRST.org EPSS.

How urgent is this, really

Where this sits among everything scored

Real-World Exposure

2 pkgs affected

🐍omero-web🐍omero-figure

Real-time download stats are indexed for npm and PyPI packages. This vulnerability affects PyPI packages — download data is not available via public APIs for these ecosystems.

Description

OMERO.web provides a web based client and plugin infrastructure. In versions prior to 5.11.0, a variety of templates do not perform proper sanitization through HTML escaping. Due to the lack of sanitization and use of jQuery.html(), there are a whole host of cross-site scripting possibilities with specially crafted input to a variety of fields. This issue is patched in version 5.11.0. There are no known workarounds aside from upgrading.

Affected Packages

2 total 2 fixed

Ecosystem	Package	Vulnerable range	Fix
🐍PyPI	`omero-web`	all versions	5.11.0`pip install --upgrade 'omero-web==5.11.0'`
🐍PyPI	`omero-figure`	all versions	4.4.1`pip install --upgrade 'omero-figure==4.4.1'`

Affected Products

2 products · 2 configurations

Application

omero-figureopenmicroscopy

< 4.4.1

range

Application

omero-webopenmicroscopy

< 5.11.0

range

Detection & mitigation playbook

Open-source dependency

Detect
Scan your dependency tree (package-lock.json, pnpm-lock.yaml, requirements.txt, go.sum, etc.) for omero-web, including transitive dependencies — a direct dependency you never call can still pull in a vulnerable version.
Fix
Update omero-web to 5.11.0 or later, then make sure no transitive (indirect) dependency still pins the vulnerable range — O3 confirms CVE-2021-41132 is resolved across your whole dependency graph.
Workarounds
Escape or sanitise the affected output on the server side rather than relying on client-side filtering, and add a Content-Security-Policy that blocks inline script execution so injected markup cannot run even if it reaches the page.

Frequently Asked Questions

OMERO.web provides a web based client and plugin infrastructure. In versions prior to 5.11.0, a variety of templates do not perform proper sanitization through HTML escaping. Due to the lack of sanitization and use of ``jQuery.html()``, there are a whole host of cross-site scripting possibilities with specially crafted input to a variety of fields. This issue is patched in version 5.11.0. There are no known workarounds aside from upgrading.

O3 Security · Impact-Aware SCA

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Find it across PyPI, including transitive dependencies.

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CVSS Score

6.1/10CVSS v3 base

Vector breakdown

Attack Vector

Network

Attack Complexity

Low

Privileges Required

None

User Interaction

Required

Scope

Changed

Confidentiality

Low

Integrity

Low

Availability

None

Raw vector

CVSS:3.1/AV:N/AC:L/PR:N/UI:R/S:C/C:L/I:L/A:N

CWE Classification

CWE-116CWE-116 CWE-79Cross-site Scripting (XSS)

Weaponization

No Nuclei template, Metasploit module or public proof-of-concept found.

OpenSSF Scorecard

Package health score

omero-web

5.5/10

Code-Review3/10

Maintained10/10

Branch-Protection0/10

Assessed Nov 2, 2026

Timeline

Disclosed

Oct 14, 2021

Last updated

Nov 10, 2026

Identifiers

CVE-2021-41132

GHSA-g67g-hvc3-xmvf

PYSEC-2021-372

PYSEC-2021-379

References

Advisorygithub.com · GHSA g67g hvc3 xmvf Advisoryopenmicroscopy.org · 2021 SV3 Advisorynvd.nist.gov · CVE 2021 41132 Fixgithub.com · 0168067accde5e635341b3c714b1d53ae92ba424 Webgithub.com · PYSEC 2021 379.yaml Webgithub.com · PYSEC 2021 372.yaml Webopenmicroscopy.org · 2021 SV3 Packagegithub.com · omero web

Related vulnerabilities

Also affects omero-web

This CVE is medium severity; 5 of 6 other CVEs affecting omero-web are rated as high or higher (top: high).

GHSA-j4gv-6x9v-v23gCVE-2025-54791CVE-2024-35180CVE-2020-7932CVE-2021-21377CVE-2021-21376

Same weakness: CWE-116

This CVE is medium severity; 1 of 2 other CVEs with CWE-116 is rated as high or higher (top: moderate).

CVE-2026-126063CVE-2026-109476Browse all CWE-116

Provenance

Sources

OSV.devNVDFIRST.org (EPSS)

Last verifiedNov 10, 2026