CVE-2021-22681
CRITICALCVE-2021-22681 is a critical-severity (CVSS 9.8) CWE-522 vulnerability. It is in CISA's Known Exploited Vulnerabilities catalog (added 2026-03-05) — treat it as actively exploited and patch now. O3 Security confirms whether CVE-2021-22681 is actually reachable in your code before you act, and blocks exploitation at runtime until you patch.
Rockwell Automation Studio 5000 Logix Designer Versions 21 and later, and RSLogix 5000 Versions 16 through 20 use a key to verify Logix controllers are communicating with Rockwell Automation…
Exploitation Status
Actively exploited in the wild
- Confirmed by CISA's Known Exploited Vulnerabilities catalog on 2026-03-05. Federal agencies were required to remediate by 2026-03-26.
- CISA assesses this as automatable — exploitation doesn’t require manual, per-target effort, which raises the odds of mass scanning and opportunistic attacks.
- A successful exploit gives an attacker total control of the affected component, not partial access.
Exploitation and automatability from CISA (KEV catalog and SSVC triage) for CVE-2021-22681.
EPSS Exploitation Probability
EPSS (Exploit Prediction Scoring System) is a daily probability model maintained by FIRST.org. It estimates the likelihood a CVE will be exploited in production environments within the next 30 days, derived from real-world threat intelligence signals.
How urgent is this, really
CVE-2021-22681 plotted by exploitation likelihood (EPSS) against impact (CVSS). The shaded corner — EPSS 50%+ and CVSS 7.0+ — is where this CVE sits: patch-first territory.
Where this sits among everything scored
Of 0 CVEs with a current EPSS score, this one falls in the 50–90% band (highlighted). Real counts from FIRST.org, not a sample — log-scaled since the landscape is heavily right-skewed.
Description
Rockwell Automation Studio 5000 Logix Designer Versions 21 and later, and RSLogix 5000 Versions 16 through 20 use a key to verify Logix controllers are communicating with Rockwell Automation CompactLogix 1768, 1769, 5370, 5380, 5480: ControlLogix 5550, 5560, 5570, 5580; DriveLogix 5560, 5730, 1794-L34; Compact GuardLogix 5370, 5380; GuardLogix 5570, 5580; SoftLogix 5800. Rockwell Automation Studio 5000 Logix Designer Versions 21 and later and RSLogix 5000: Versions 16 through 20 are vulnerable because an unauthenticated attacker could bypass this verification mechanism and authenticate with Rockwell Automation CompactLogix 1768, 1769, 5370, 5380, 5480: ControlLogix 5550, 5560, 5570, 5580; DriveLogix 5560, 5730, 1794-L34; Compact GuardLogix 5370, 5380; GuardLogix 5570, 5580; SoftLogix 5800.
Detection & mitigation playbook
VulnerabilityDetect
Scan your dependency tree (package-lock.json, pnpm-lock.yaml, requirements.txt, go.sum, etc.) for the affected component. O3's reachability analysis confirms whether the vulnerable code path is actually invoked in your application, so you act on real exposure instead of every transitive match.
Remediation status
No patched version of the affected component has shipped for CVE-2021-22681 yet. Where your build allows, override or pin the dependency away from the vulnerable range, and apply any maintainer-recommended mitigation.
Mitigate without a patch
If you can't upgrade right away: gate or disable the affected feature, validate untrusted input at the boundary, and avoid passing attacker-controlled data into the vulnerable path. O3's runtime protection blocks exploitation in production as an interim safeguard until the upgrade lands.
How O3 protects you
O3 pinpoints whether CVE-2021-22681 is reachable in your code and exactly where to fix it, then blocks exploitation in production at runtime until the patched version is deployed.
Tailored to CVE-2021-22681. Runtime protection reduces exposure until a permanent patch is applied and verified — it complements patching, it doesn't replace it.
Frequently Asked Questions
Is CVE-2021-22681 in your dependencies?
O3 detects CVE-2021-22681 across dependencies and uses function-level reachability to confirm whether the vulnerable code path is actually reachable — not just present. No false positives.